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Breyanzi is a CD19-directed chimeric antigen receptor (CAR) T cell therapy for the treatment of relapsed or refractory large B-cell lymphoma.
February 8, 2021
By: Kristin Brooks
Managing Editor, Contract Pharma
Bristol Myers Squibb received approval from the FDA for Breyanzi (lisocabtagene maraleucel; liso-cel), a CD19-directed chimeric antigen receptor (CAR) T cell therapy for the treatment of relapsed or refractory (R/R) large B-cell lymphoma (LBCL) after two or more lines of systemic therapy. The approval is based on data from the TRANSCEND NHL trial in which 268 patients with R/R LBCL received Breyanzi. In the study, 192 patients were treated with Breyanzi at the dose of 50 to 110 x 106 CAR-posi...
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